abstract:INTRODUCTION:Primary membranous nephropathy (PMN) is one common cause of end-stage kidney disease. There is no optimal treatment for PMN patients with sub-nephrotic proteinuria currently. Tripterygium wilfordii polyglycoside (TWG) is a widely used traditional medicine in China and has been used to treat nephropathy for...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1918555
更新日期:2021-12-01 00:00:00
abstract::The SOCS1/JAK2/STAT3 axis is strongly associated with tumor growth and progression, and participates in cytokine secretion in many diseases. However, the effects of the SOCS1/JAK2/STAT3 axis in experimental subarachnoid hemorrhage remain to be studied. A subarachnoid hemorrhage model was established in rats by infusin...
journal_title:Neural regeneration researchpub_type: 杂志文章
doi:10.4103/1673-5374.313049
更新日期:2021-12-01 00:00:00
abstract::Facial synkinesis is a troublesome sequelae of facial nerve malfunction. It is difficult to recover from synkinesis, despite improved surgical techniques for isolating the peripheral facial nerve branches. Furthermore, it remains unclear whether long-term dysfunction of motor control can lead to irreversible plasticit...
journal_title:Neural regeneration researchpub_type: 杂志文章
doi:10.4103/1673-5374.313055
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Acute coronary syndrome (ACS) is prevalent in continuous ambulatory peritoneal dialysis (CAPD) patients. However, the association between the apoprotein profile and ACS is not well known. Therefore, we aimed to investigate the relationship between apoproteins and ACS in CAPD patients. METHODS:Eighty-one CAP...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1918556
更新日期:2021-12-01 00:00:00
abstract::Porcine fat deposition is an important economic trait of pig breeds, and understanding the gene regulatory network in adipocytes is essential for modern pig breeding. In a previous study, we demonstrated that miR-29a negatively regulates the differentiation of porcine adipocytes. In this study, we investigated the rol...
journal_title:Adipocytepub_type: 杂志文章
doi:10.1080/21623945.2021.1917811
更新日期:2021-12-01 00:00:00
abstract::Osteoarthritis (OA) is a chronic inflammatory joint disease. Increased apoptosis of chondrocytes contributes to cartilage degradation in OA pathogenesis. The function of lncRNA MCM3AP-AS1 in regulating the viability of chondrocytes still awaits further elaboration. In this work, MCM3AP-AS1, miR-138-5p and SIRT1 mRNA e...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1905247
更新日期:2021-12-01 00:00:00
abstract::Anti-breast cancer action of novel human carbonic anhydrase IX (hCA IX) inhibitor BSM-0004 has been investigated using in vitro and in vivo models of breast cancer. BSM-0004 was found to be a potent and selective hCA IX inhibitor with a Ki value of 96 nM. In vitro anticancer effect of BSM-0004 was analysed against MCF...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2021.1909580
更新日期:2021-12-01 00:00:00
abstract::Osteosarcoma (OS) is an aggressive malignant tumor with a high rate of lung metastasis and a lack of therapeutic targets. Although the anomalous expression of long non-coding RNA (lncRNA) has been extensively documented in human cancer, its contribution to OS metastasis remains poorly understood. In this study, we fou...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1920326
更新日期:2021-12-01 00:00:00
abstract::Meaningful activities in dementia care can promote the co-construction of narrative identity in caregiving relationships, helping to preserve the sense of self in people with dementia.Purpose: Informed by symbolic interactionism and Deweyan transactionalism, the aim of this study was to develop a transactional model o...
journal_title:International journal of qualitative studies on health and well-beingpub_type: 杂志文章
doi:10.1080/17482631.2021.1920349
更新日期:2021-12-01 00:00:00
abstract::Factor V Leiden G1691A (FVL) and Factor II prothrombin G20210A (PGM) mutations are the leading causes of thrombophilia. In this study, we have investigated the prevalence of the FVL G1691A and PGM G20210A single nucleotide polymorphisms (SNPs) among Libyan deep vein thrombosis (DVT) and myocardial infarction (MI) pati...
journal_title:The Libyan journal of medicinepub_type: 杂志文章
doi:10.1080/19932820.2020.1857525
更新日期:2021-12-01 00:00:00
abstract::A fundamental mechanism that drives the propagation of electrical signals in the nervous system is the activation of voltage-gated sodium channels. The sodium channel subtype Nav1.7 is critical for the transmission of pain-related signaling, with gain-of-function mutations in Nav1.7 resulting in various painful pathol...
journal_title:Channels (Austin, Tex.)pub_type: 杂志文章
doi:10.1080/19336950.2020.1860382
更新日期:2021-12-01 00:00:00
abstract::Drosophila pseudoobscura is a classic model system for the study of evolutionary genetics and genomics. Given this long-standing interest, many genome sequences have accumulated for D. pseudoobscura and closely related species D. persimilis, D. miranda, and D. lowei. To facilitate the exploration of genetic variation ...
journal_title:Flypub_type: 杂志文章
doi:10.1080/19336934.2020.1864201
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Oscillometric pulse wave velocity (o-PWV) represents an attractive, non invasive and non operator-dependent method to estimate arterial stiffness. Tonometric carotid-femoral measurements (cf-PWV),are considered the gold-standard for non-invasive aortic stiffness assessment. To date, no studies in the general...
journal_title:Annals of medicinepub_type: 杂志文章
doi:10.1080/07853890.2020.1794538
更新日期:2021-12-01 00:00:00
abstract:PURPOSE:To compare perioperative outcomes and long-term renal function changes between prior stenting (PS) and not prior stenting (NPS) before flexible ureteroscopy lithotripsy (f-URS) for solitary kidney patients. METHODS:Solitary kidney patients with 10-30 mm renal stones were enrolled in this historical control stu...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1872625
更新日期:2021-12-01 00:00:00
abstract:BACKGROUND:Intradialytic hypotension (IDH) is a common complication in maintaining hemodialysis (MHD) patients. Immune activation might be part of the mechanisms. However, the association between pro-inflammatory cytokines and blood pressure (BP) has not been deeply explored. So we aim to evaluate the potential role of...
journal_title:Renal failurepub_type: 杂志文章
doi:10.1080/0886022X.2021.1871921
更新日期:2021-12-01 00:00:00
abstract:CONTEXT:Sauropus brevipes Müll. Arg. (Phyllanthaceae) has been used as an effective ingredient in a decoction for the treatment of diarrhoea. However, there was no report on its modulatory role in inflammation. OBJECTIVE:This study investigates anti-inflammatory effect of S. brevipes in various inflammation models. M...
journal_title:Pharmaceutical biologypub_type: 杂志文章
doi:10.1080/13880209.2020.1866024
更新日期:2021-12-01 00:00:00
abstract::Ligustrazine, an alkaloid monomer extracted from Chuanxiong Rhizoma, has the function of protecting nerve cells. However, the effect and mechanism of ligustrazine on retinal ischemia/reperfusion (I/R) injury still need to be clarified. In our study, retinal ganglion cells (RGC-5) were used to establish a retinal I/R i...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1880060
更新日期:2021-12-01 00:00:00
abstract::The aim of this work is to survey the potential of cubogel as an ocular dosage form to boost the corneal permeability of Dorzolamide Hydrochloride DZ; an antiglaucomal drug. DZ-loaded cubosomal dispersions were prepared according to Box-Behnken design, where the effect of independent variables; Monoolein MO concentrat...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2021.1872740
更新日期:2021-12-01 00:00:00
abstract::Injectable hydrogels attract more attention to hard tissue engineering for the fulfilment of the defects with irregular shapes. Therefore, the researchers investigated the biocompatibility and immune response to the injectable PCL-PEG-PCL-Col/nHA hydrogels in a mouse model. The histological examination was done via H&...
journal_title:Artificial cells, nanomedicine, and biotechnologypub_type: 杂志文章
doi:10.1080/21691401.2021.1877153
更新日期:2021-12-01 00:00:00
abstract::Most of the current industrial processes for L-leucine production are based on fermentation, usually in fed-batch operation mode. Although the culture technology has advanced in recent decades, the process still has significant drawbacks. To solve these problems, we investigated the effects of chemostat culture condit...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1874693
更新日期:2021-12-01 00:00:00
abstract::As a type of non-coding RNA, circular RNA (circRNA) figures prominently in human cancer progression. Nonetheless, the expression, function, and regulatory mechanism of circ_0001287 in non-small cell lung cancer (NSCLC) remain obscure. In this work, quantitative real-time polymerase chain reaction (qRT-PCR) was impleme...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2021.1872191
更新日期:2021-12-01 00:00:00
abstract::In this paper, the efficiency of the carbonic anhydrase (CA) enzyme in accelerating the hydration of CO2 is evaluated using a measurement system which consists of a vessel in which a gaseous flow of mixtures of nitrogen and CO2 is bubbled into water or water solutions containing a known quantity of CA enzyme. The pH v...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1864631
更新日期:2021-12-01 00:00:00
abstract:OBJECTIVE:To assess clinical outcomes of newly diagnosed extranodal NK/T-cell lymphoma nasal-type (ENKTL) patients treated with L-asparaginase-containing chemotherapy as first-line chemotherapy. MATERIALS AND METHODS:We retrospectively reviewed data of new ENKTL patients in Siriraj Hospital, Thailand during 2012-2016....
journal_title:Hematology (Amsterdam, Netherlands)pub_type: 杂志文章
doi:10.1080/16078454.2020.1867783
更新日期:2021-12-01 00:00:00
abstract::Newly synthesised benzimidazole/benzotiazole derivatives bearing amidino, namely 3,4,5,6-tetrahydropyrimidin-1-ium chloride, substituents have been evaluated for their potential antitumor activity in vitro. Compounds and standard drugs (doxorubicin, staurosporine and vandetanib) were tested on three human lung cancer ...
journal_title:Journal of enzyme inhibition and medicinal chemistrypub_type: 杂志文章
doi:10.1080/14756366.2020.1850711
更新日期:2021-12-01 00:00:00
abstract::Fenretinide (4-HPR), a synthetic retinoid, has attracted attention for its anti-inflammation activity. However, few studies have evaluated the effects of 4-HPR on ulcerative colitis (UC). The present study was performed to investigate the therapeutic effects of 4-HPR on UC, and to explore the mechanisms mainly focused...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2020.1859259
更新日期:2021-12-01 00:00:00
abstract::The genome of SARS-CoV-2 encodes two viral proteases (NSP3/papain-like protease and NSP5/3C-like protease) that are responsible for cleaving viral polyproteins during replication. Here, we discovered new functions of the NSP3 and NSP5 proteases of SARS-CoV-2, demonstrating that they could directly cleave proteins invo...
journal_title:Emerging microbes & infectionspub_type: 杂志文章
doi:10.1080/22221751.2020.1870414
更新日期:2021-12-01 00:00:00
abstract::Convergence of virulence and antibiotic-resistance has been reported in Klebsiella pneumoniae, but not in Klebsiella variicola. We, hereby, report the detection and genomic characterization of hypervirulent and hypermucoviscous K. pneumoniae and K.variicola recovered in Chile from health-care associated infections, wh...
journal_title:Virulencepub_type: 杂志文章
doi:10.1080/21505594.2020.1859274
更新日期:2021-12-01 00:00:00
abstract::Purpose: In this qualitative study we explored how young women living in Sweden with ethnic and cultural roots in the Middle East and East Africa comply with or resist so-called honour norms and how they perceive that these norms affect their living conditions. Method: In depth interviews were performed with 14 young ...
journal_title:International journal of qualitative studies on health and well-beingpub_type: 杂志文章
doi:10.1080/17482631.2020.1862480
更新日期:2021-12-01 00:00:00
abstract::To study whether ropivacaine inhibits the proliferation and migration of colon cancer cells through ITGB1 (Integrin beta-1). First, the effect of ropivacaine on cell proliferation and migration was detected by MTT and Transwell. DAPI staining, annexin V staining and Western blot were used to detect the expression of a...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2020.1857120
更新日期:2021-12-01 00:00:00
abstract::Hepatic stellate cells (HSCs) play a crucial role in the progression of liver fibrosis, which can be considered as the specific therapeutic target of anti-fibrotic treatment. Targeted induction of HSCs to hepatocytes via delivery of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated p...
journal_title:Drug deliverypub_type: 杂志文章
doi:10.1080/10717544.2020.1850917
更新日期:2021-12-01 00:00:00
abstract::The screening and treatment of laryngeal squamous cell carcinoma (LSCC) still perplexes clinicians, making it necessary to explore new markers. To this end, this research examined the underlying molecular mechanism of LSCC based on high-throughput datasets (n = 249) from multiple databases. It also identified transcri...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2020.1862527
更新日期:2021-12-01 00:00:00
abstract::Many of the Orchidaceae species are threatened due to environmental changes and over exploitation for full fill global demands. The main objective of this article was critically analyzed the recent global distribution of Orchidaceae diversity, its disease patterns, microbial disease identification, detection, along wi...
journal_title:Bioengineeredpub_type: 杂志文章
doi:10.1080/21655979.2020.1853447
更新日期:2021-12-01 00:00:00
abstract::A new approach to produce biodegradable low-temperature greases, based on cellulose acetate butyrate (CAB) that dissolves in the medium of acetyl tributyl citrate (ATBC) at high temperatures and produces a gel during cooling because of phase separation, is proposed. Rheological properties of CAB solutions and gels in ...
journal_title:Carbohydrate polymerspub_type: 杂志文章
doi:10.1016/j.carbpol.2021.118509
更新日期:2021-11-15 00:00:00
abstract::The primary purpose of this study was to develop an innovative chitosan (CS) modified polylactic acid (PLA) nanospheres for enhancing the bioavailability of 1, 2-benzisothiazolin-3-one (BIT). The cellular uptake efficiency was corresponded positively to the quantity of CS coated on BIT-PLA nanospheres against E. coli ...
journal_title:Carbohydrate polymerspub_type: 杂志文章
doi:10.1016/j.carbpol.2021.118406
更新日期:2021-11-15 00:00:00
abstract::Levodopa (biological precursor of dopamine) is sometimes used instead of dopamine for synthesis of highly adhesive polycatecholamine coatings on different materials. However, in comparison of polydopamine, little is known about biological safety of poly(levodopa) coatings and their efficacy in binding of therapeutical...
journal_title:Carbohydrate polymerspub_type: 杂志文章
doi:10.1016/j.carbpol.2021.118485
更新日期:2021-11-15 00:00:00
abstract::In this study, different types of starch-based double emulsion (SDE) structures were developed to improve the bioavailability of astaxanthin (AST). Droplet size, microstructure, zeta potential of the AST-loaded SDEs were measured during in vitro digestion model. Compared with the C-type SDEs prepared with high amylose...
journal_title:Carbohydrate polymerspub_type: 杂志文章
doi:10.1016/j.carbpol.2021.118475
更新日期:2021-11-15 00:00:00
abstract::Nowadays, cancer is one of the most prominent issues related to human health since it causes more than one-tenth of death cases throughout the world. On the other hand, routine therapeutic approaches in cancer suppression such as radiation therapy, chemotherapy, surgery, etc. due to their undesirable therapeutic outpu...
journal_title:Carbohydrate polymerspub_type: 杂志文章,评审
doi:10.1016/j.carbpol.2021.118464
更新日期:2021-11-15 00:00:00
abstract::Drugs re-purposing due to COVID-19 virus has declared a number of useful candidates for treatment and prevention of the virus. Ivermectin (IVM) has gained much popularity due to a strong background of magical applications against a broad spectrum of pathogens. The in- vitro studies of ivermectin have shown promise, th...
journal_title:Journal of molecular structurepub_type: 杂志文章
doi:10.1016/j.molstruc.2021.130808
更新日期:2021-11-05 00:00:00
abstract::Six sequential spectrophotometric-based univariate methods were developed and validated for the simultaneous estimation of three novel anticancer drugs vandetanib (VAN), dasatinib (DAS), and sorafenib (SOR) in a mixture, without the requirement for separation. These methods are novel, simple, precise, and accurate. Di...
journal_title:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopypub_type: 杂志文章
doi:10.1016/j.saa.2021.119987
更新日期:2021-11-05 00:00:00
abstract::The effect of manganese (Mn) on protein conformation is closely related to its chemical species. To further realize the behavior of different species of Mn in vivo, this study is designed to analyze the separate and simultaneous interactions of Mn(ii) and Mn(iii) with bovine serum albumin (BSA) using multi-spectroscop...
journal_title:Spectrochimica acta. Part A, Molecular and biomolecular spectroscopypub_type: 杂志文章
doi:10.1016/j.saa.2021.119981
更新日期:2021-11-05 00:00:00